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CI63
Recombinant Human 3-hydroxyacyl-CoA dehydrogenase type-2/HSD17B10
10ug
1400
1260
现货
国产
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CI63
Recombinant Human 3-hydroxyacyl-CoA dehydrogenase type-2/HSD17B10
50ug
3600
3240
现货
国产
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CI63
Recombinant Human 3-hydroxyacyl-CoA dehydrogenase type-2/HSD17B10
500ug
12320
11088
现货
国产
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CI63
Recombinant Human 3-hydroxyacyl-CoA dehydrogenase type-2/HSD17B10
1mg
17600
15840
现货
国产
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Catalog# CI63 Source Human cells Description Recombinant Human HSD17B10 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Met1-Pro261) of Human HSD17B10 fused with a polyhistidine tag at the C-terminus. Names 3-hydroxyacyl-CoA dehydrogenase type-2,17-beta-hydroxysteroid dehydrogenase 10,17-beta-HSD 10,3-hydroxy-2-methylbutyryl-CoA dehydrogenase,3-hydroxyacyl-CoA dehydrogenase type II,HSD17B10 Accession # Q99714 Formulation Supplied as a 0.2 μm filtered solution of 20mM Trsi HCL pH-8,0.1M NaCl,1mM DTT & 10% glycerol Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADV TSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIR LVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVMT IAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRMQ PVDHHHHHHBackground 3-hydroxyacyl-CoA dehydrogenase type-2(HSD17B10) belongs to the short-chain dehydrogenases/reductases (SDR) family. HSD17B10 is ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD. It functions in mitochondrial tRNA maturation. It catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. It also catalyzes the third step in the beta-oxidation of fatty acids and carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. The protein exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, HSD17B10 may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).