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CJ03
Recombinant Human ALK-3/Bone morphogenetic protein receptor type-1A/BMPR-IA
10ug
400
360
现货
国产
-
CJ03
Recombinant Human ALK-3/Bone morphogenetic protein receptor type-1A/BMPR-IA
50ug
1200
1080
现货
国产
-
CJ03
Recombinant Human ALK-3/Bone morphogenetic protein receptor type-1A/BMPR-IA
500ug
9840
8856
现货
国产
-
CJ03
Recombinant Human ALK-3/Bone morphogenetic protein receptor type-1A/BMPR-IA
1mg
14080
12672
现货
国产
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Catalog# CJ03 Source E. coli Description Recombinant Mouse ALK-3/BMPR-1A is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Gln24-Arg152) of Mouse ALK-3 fused with FC-6His at the C-terminus. Names ALK-3/Bone morphogenetic protein receptor type-1A/BMP type-1A receptor/BMPR-1A/Activin receptor-like kinase 3/BMP-2/BMP-4 receptor/Serine/threonine-protein kinase receptor R5/SKR5/CD292/Bmpr1a/Bmpr/Acvrlk3 Accession # P36895 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 3X PBS.
Please aliquot the reconstituted solutionStorage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 5 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence QNLDSMLHGTGMKSDLDQKKPENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEE DDQGETTLTSGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRV DDIEGRMDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDG SFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH*Background ALK-3 is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. The BMP receptors consists of the type I receptors BMPR1A and BMPR1B and the type I I receptor BMPR2. Seven known type I serine/threonine kinases and five mammalian type II serine/threonine kinase receptors function in TGF-beta superfamily signal transduction. The downstream molecules of the type I BMP receptors include the Smad (Smad1, 5 and 8) proteins that are phosphorylated in a ligand-dependent manner, and relay the BMP signal from the receptors to target genes in the nucleus. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. ALK-3 contains a GS domain and a protein kinase domain. ALK-3 is widely expressed. Defects in BMPR1A gene are a cause of a significant proportion of cases of Juvenile polyposis syndrome (JPS).