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CI86
Recombinant Human Ganglioside GM2 activator/GM2A
10ug
1400
1260
现货
国产
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CI86
Recombinant Human Ganglioside GM2 activator/GM2A
50ug
3600
3240
现货
国产
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CI86
Recombinant Human Ganglioside GM2 activator/GM2A
500ug
12320
11088
现货
国产
-
CI86
Recombinant Human Ganglioside GM2 activator/GM2A
1mg
17600
15840
现货
国产
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Catalog# CI86 Source Human cells Description Recombinant Human Ganglioside GM2 activator is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Ser32-Ile193) of Human GM2A fused with a polyhistidine tag at the C-terminus. Names Ganglioside GM2 activator,Cerebroside sulfate activator protein,GM2-AP,Sphingolipid activator protein 3,SAP-3 Accession # P17900 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,pH7.5 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence SSFSWDNCDEGKDPAVIRSLTLEPDPIVVPGNVTLSVVGSTSVPLSSPLKVDLVLEKEVAGLWIK IPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLELPS WLTTGNYRIESVLSSSGKRLGCIKIAASLKGIVDHHHHHHBackground Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A (HEXB). HEXB together with GM2A, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. GM2A accommodate several single chain phospholipids and fatty acids, is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.