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CH82
Recombinant Human PTPRN/Receptor-type tyrosine-protein phosphatase-like N
10ug
1200
1080
现货
国产
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CH82
Recombinant Human PTPRN/Receptor-type tyrosine-protein phosphatase-like N
50ug
3520
3168
现货
国产
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CH82
Recombinant Human PTPRN/Receptor-type tyrosine-protein phosphatase-like N
500ug
12320
11088
现货
国产
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CH82
Recombinant Human PTPRN/Receptor-type tyrosine-protein phosphatase-like N
1mg
17600
15840
现货
国产
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Catalog# CH82 Source E.coli Description Recombinant Human ZBTB9 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Lys473) of Human ZBTB9 fused with a 6His tag at the N-terminus. Names Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512 Accession # Q16849 Formulation Supplied as a 0.2 μm filtered solution of PBS，pH7.4 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MGSSHHHHHHSSGLVPRGSHMQDKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGPPE PSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANGGGGSGGGGSGGGGSWQMVWESGCTVIVM LTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFL SWPAEGTPASTRPLLBackground Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity, may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.