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CI64
Recombinant Human Thymidine kinase, cytosolic/TK1
10ug
1200
1080
现货
国产
-
CI64
Recombinant Human Thymidine kinase, cytosolic/TK1
50ug
3520
3168
现货
国产
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CI64
Recombinant Human Thymidine kinase, cytosolic/TK1
500ug
12320
11088
现货
国产
-
CI64
Recombinant Human Thymidine kinase, cytosolic/TK1
1mg
17600
15840
现货
国产
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Catalog# CI64 Source Human cells Description Recombinant Human TK1 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Met1-Asn234) of Human TK1 fused with a polyhistidine tag at the C-terminus. Names Thymidine kinase, cytosolic，TK1 Accession # P04183 Formulation Supplied as a 0.2 μm filtered solution of PBS,pH7.4 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSF CTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQR KPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASG QPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPANVDHHHHHHBackground Thymidine kinase 1(TK1) belongs to the thymidine kinase family. It is located in the cytoplasm, and phosphorylated on Ser-13 in mitosis during post-translational modification. Two forms of this protein have been identified in animal cells, one in cytosol TK1 and one in mitochondria TK2. Thymidine kinases have a key function in the synthesis of DNA and thereby in cell division, as they are part of the unique reaction chain to introduce deoxythymidine into the DNA. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle, while it is very low in resting cells. TK1 acts as a homotetramer, and can transform thymidime to thymidine 5'-phosphate with the help of ATP