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CE36
Recombinant Human Aldo-keto Reductase 1C4/AKR1C4
10ug
1200
1080
现货
国产
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CE36
Recombinant Human Aldo-keto Reductase 1C4/AKR1C4
50ug
3520
3168
现货
国产
-
CE36
Recombinant Human Aldo-keto Reductase 1C4/AKR1C4
500ug
12320
11088
现货
国产
-
CE36
Recombinant Human Aldo-keto Reductase 1C4/AKR1C4
1mg
17600
15840
现货
国产
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Catalog# CE36 Source E.coli Description Recombinant Human Aldo-Keto Reductase 1C4/AKR1C4 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Tyr323) of Human AKR1C4 fused with a 6His tag at the N-terminus. Names Aldo-Keto Reductase Family 1 Member C4, 3-Alpha-HSD1, 3-Alpha-Hydroxysteroid Dehydrogenase Type I, Chlordecone Reductase, CDR, Dihydrodiol Dehydrogenase 4, DD-4, DD4, HAKRA, AKR1C4, CHDR Accession # P17516 Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence MGSSHHHHHHSSGLVPRGSHMDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAG FRHIDSAYLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDY VDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEM ILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRY VVMDFLMDHPDYPFSDEYBackground Aldo-Keto Reductase 1C4/AKR1C4 is a member of the aldo/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-α-Androstan-3-α,17-β-diol (3-α-diol). In addition, AKR1C4 also has some 20-α-Hydroxysteroid Dehydrogenase activity.