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CA46
Recombinant Human APP/Amyloid beta A4 protein
10ug
1200
1080
现货
国产
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CA46
Recombinant Human APP/Amyloid beta A4 protein
50ug
3520
3168
现货
国产
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CA46
Recombinant Human APP/Amyloid beta A4 protein
500ug
12320
11088
现货
国产
-
CA46
Recombinant Human APP/Amyloid beta A4 protein
1mg
17600
15840
现货
国产
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Catalog# CA46 Source Human Cells Description Recombinant Human Amyloid β A4 Protein/APP is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Leu18-Leu305) of Human APP fused with a polyhistidine tag at the C-terminus. Names Amyloid Beta A4 Protein, ABPP, APPI, APP, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-II, PN-II, APP Accession # P05067 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence LEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQI TNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETH LHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGG ADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTT TTTESVEEVVREKWYKEVHSGQARWLMLVDHHHHHHBackground Amyloid β A4 Protein (APP) is an integral membrane protein that belongs to the APP family. APP contains one BPTI/Kunitz inhibitor domain. APP is expressed in all fetal tissues, with the highest expression levels observed in the brain, kidney, heart, and spleen. APP is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion, and axonogenesis. APP plays a role in cell mobility and transcription regulation through protein-protein interactions. APP also promotes transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Mutations in APP are associated with Alzheimer's disease.