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C105
Recombinant Human Bcl-w/Bcl-2-like protein 2
10ug
640
576
现货
国产
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C105
Recombinant Human Bcl-w/Bcl-2-like protein 2
50ug
2000
1800
现货
国产
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C105
Recombinant Human Bcl-w/Bcl-2-like protein 2
500ug
12320
11088
现货
国产
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C105
Recombinant Human Bcl-w/Bcl-2-like protein 2
1mg
17600
15840
现货
国产
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Catalog# C105 Source E.coli Description Recombinant Human Bcl-2-Llike Protein 2/BCL2L2 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Thr172) of Human BCL2L2. Names Bcl-2-Like Protein 2, Bcl2-L-2, Apoptosis Regulator Bcl-W, BCL2L2, BCLW, KIAA0271 Accession # Q92843 Formulation Supplied as a 0.2 μm filtered solution of 25mM HEPES, 100mM KCl, 20% Glycerol, pH 7.5 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLA AQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYL ETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTLEHHHHHHBackground Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in the brain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.