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C450
Recombinant Human Carboxylesterase 1/CES1
10ug
1200
1080
现货
国产
-
C450
Recombinant Human Carboxylesterase 1/CES1
50ug
3520
3168
现货
国产
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C450
Recombinant Human Carboxylesterase 1/CES1
500ug
12320
11088
现货
国产
-
C450
Recombinant Human Carboxylesterase 1/CES1
1mg
17600
15840
现货
国产
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Catalog# C450 Source HEK293 Description Recombinant Human Carboxylesterase 1/CES1 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (His19-Glu562) of Human CES1 fused with a polyhistidine tag at the C-terminus. Names Liver Carboxylesterase 1, Acyl-Coenzyme A:Cholesterol Acyltransferase, ACAT, Brain Carboxylesterase hBr1, Carboxylesterase 1, CE-1, hCE-1, Cocaine Carboxylesterase, Egasyn, HMSE, Methylumbelliferyl-Acetate Deacetylase 1, Monocyte/Macrophage Serine Esteras Accession # P23141-3 Formulation Supplied as a 0.2 μm filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence HPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSY PPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGA ASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPG SVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTT SAVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHT VPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDD TVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFS VFGAPFLKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKL KDKEVAFWTNLFAKKAVEKPPQTEVDHHHHHHBackground Carboxylesterase 1 (CES1) is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds. These enzymes have broad substrate specificity ranging from small molecule esters such as phenylester to long chain fatty acid esters and thioesters. They are major determinants of the pharmacokinetic behavior of most therapeutic agents containing an ester or amide bond. CES1 shares the serine hydrolase fold observed in other esterases. CES1 hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. CES1 participates in detoxification of drugs such as cocaine and heroin in serum and liver. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.