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CA32
Recombinant Human Carboxypeptidase B2/CPB2
10ug
480
432
现货
国产
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CA32
Recombinant Human Carboxypeptidase B2/CPB2
50ug
1440
1296
现货
国产
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CA32
Recombinant Human Carboxypeptidase B2/CPB2
500ug
12320
11088
现货
国产
-
CA32
Recombinant Human Carboxypeptidase B2/CPB2
1mg
17600
15840
现货
国产
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Catalog# CA32 Source Human Cells Description Recombinant Human Carboxypeptidase B2/CPB2 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Phe23-Val423) of Human CPB2 fused with a 6His tag at the C-terminus. Names Carboxypeptidase B2, Carboxypeptidase U, CPU, Plasma Carboxypeptidase B, pCPB, Thrombin-Activable Fibrinolysis Inhibitor, TAFI, CPB2 Accession # Q96IY4 Formulation Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,1mM ZnCl2,10%Glycerol,pH7.5 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 7 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by reducing SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence FQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVS GIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSS FEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDF YVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLY PESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKT SKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAV SKIAWHVIRNVLDHHHHHHBackground Carboxypeptidase B2 (CPB2) is a secreted enzyme that belongs to the peptidase M14 family. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen by the liver and circulates in the plasma as a plasminogen-bound zymogen. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides, such as kinins or anaphylatoxins, in the circulation regulating their activities. CPB2 also down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. CPB2 exhibits carboxypeptidase activity when it is activated by proteolysis at residue Arg92 of the thrombin/thrombomodulin complex. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.