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CC57
Recombinant Human Carboxypeptidase E/CPE
10ug
1200
1080
现货
国产
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CC57
Recombinant Human Carboxypeptidase E/CPE
50ug
3520
3168
现货
国产
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CC57
Recombinant Human Carboxypeptidase E/CPE
500ug
13440
12096
现货
国产
-
CC57
Recombinant Human Carboxypeptidase E/CPE
1mg
19200
17280
现货
国产
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Catalog# CC57 Source HEK293 Description Recombinant Human Carboxypeptidase E/CPE is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Arg42-Ser453) of Human CPE fused with a polyhistidine tag at the C-terminus. Names Carboxypeptidase E(CPE for short), also called Carboxypeptidase H, Enkephalin convertase, Prohormone-processing carboxypeptidase, is a peripheral membrane protein and a zinc metallo carboxypeptidase which belongs to the peptidase M14 family. Accession # P16870 Formulation Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mm NaCl,pH7.5 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence RLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPE FKYIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQPGE LKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWI MDIPFVLSANLHGGDLVANYPYDETRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSDPNRPPCR KNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWEDNKNSLI SYLEQIHRGVKGFVRDLQGNPIANATISVEGIDHDVTSAKDGDYWRLLIPGNYKLTASAPGYLAI TKKVAVPYSPAAGVDFELESFSVDHHHHHHBackground The active form of CPE cleaves C-terminal amino acid residues of the peptide, and is thus involved in the biosynthesis of peptide hormones and neurotransmitters including insulin, enkephalin, etc. It is thought that membrane-associated CPE acts as a sorting receptor for targeting regulated secretory proteins which are mostly prohormones and neuropeptides in the trans-Golgi network of the pituitary and in secretory granules into the secretory pathway. Defects in this protein are implicated in type II diabetes due to impaired glucose clearance and insulin resistance.