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CC57

Recombinant Human Carboxypeptidase E/CPE

10ug

1200

1080

现货

国产

CC57

Recombinant Human Carboxypeptidase E/CPE

50ug

3520

3168

现货

国产

CC57

Recombinant Human Carboxypeptidase E/CPE

500ug

13440

12096

现货

国产

CC57

Recombinant Human Carboxypeptidase E/CPE

1mg

19200

17280

现货

国产

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  • Catalog# CC57
    Source HEK293
    Description Recombinant Human Carboxypeptidase E/CPE is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Arg42-Ser453) of Human CPE fused with a polyhistidine tag at the C-terminus.
    Names Carboxypeptidase E(CPE for short), also called Carboxypeptidase H, Enkephalin convertase, Prohormone-processing carboxypeptidase, is a peripheral membrane protein and a zinc metallo carboxypeptidase which belongs to the peptidase M14 family.
    Accession # P16870
    Formulation Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mm NaCl,pH7.5
    Shipping The product is shipped on dry ice/ice packs.
    Storage Store at < -20°C, stable for 6 months after receipt.
    Please minimize freeze-thaw cycles.
    Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
    Endotoxin Less than 0.1 ng/µg (1 IEU/µg).
    Amino Acid Sequence
    RLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPE FKYIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQPGE LKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWI MDIPFVLSANLHGGDLVANYPYDETRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSDPNRPPCR KNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWEDNKNSLI SYLEQIHRGVKGFVRDLQGNPIANATISVEGIDHDVTSAKDGDYWRLLIPGNYKLTASAPGYLAI TKKVAVPYSPAAGVDFELESFSVDHHHHHH
    Background The active form of CPE cleaves C-terminal amino acid residues of the peptide, and is thus involved in the biosynthesis of peptide hormones and neurotransmitters including insulin, enkephalin, etc. It is thought that membrane-associated CPE acts as a sorting receptor for targeting regulated secretory proteins which are mostly prohormones and neuropeptides in the trans-Golgi network of the pituitary and in secretory granules into the secretory pathway. Defects in this protein are implicated in type II diabetes due to impaired glucose clearance and insulin resistance.