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C446
Recombinant Human 5'-Nucleotidase/NT5E/CD73
10ug
1200
1080
现货
国产
-
C446
Recombinant Human 5'-Nucleotidase/NT5E/CD73
50ug
3520
3168
现货
国产
-
C446
Recombinant Human 5'-Nucleotidase/NT5E/CD73
500ug
12320
11088
现货
国产
-
C446
Recombinant Human 5'-Nucleotidase/NT5E/CD73
1mg
17600
15840
现货
国产
-
C446
Recombinant Human CD73/5'-Nucleotidase/NT5E
10ug
1200
1080
现货
国产
-
C446
Recombinant Human CD73/5'-Nucleotidase/NT5E
50ug
3520
3168
现货
国产
-
C446
Recombinant Human CD73/5'-Nucleotidase/NT5E
500ug
12320
11088
现货
国产
-
C446
Recombinant Human CD73/5'-Nucleotidase/NT5E
1mg
17600
15840
现货
国产
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Catalog# C446 Source HEK293 Description Recombinant Human 5'-Nucleotidase/NT5E is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Trp27-Lys547) of Human NT5E fused with a polyhistidine tag at the C-terminus. Names 5'-Nucleotidase, 5'-NT, Ecto-5'-Nucleotidase, CD73, NT5E, NT5, NTE Accession # P21589 Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 2mM CaCl2, 10% Glycerol, pH 8.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence WELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTI WFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISG LYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHS GFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKY LGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQ SCRFRECNMGNLICDAMINNNLRHADETFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLP FGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRV PSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRI KVDHHHHHHBackground CD73 is a glycosyl phosphatidylinositol (GPI) anchored membrane protein that belongs to the 5'-nucleotidase family. CD73 is an ecto 5'Nucleotidase expressed by most cell types. CD73 hydrolyzes extracellular nucleotides into membrane permeable nucleosides. CD73 is one of several enzymes responsible for the production of extracellular adenosine, a signaling molecule that is involved in responses to inflammation and tissue injury. CD73 is a lymphocyte maturation marker that has functions independent of its catalytic activity. CD73 is also a regulator of leukocyte extravasation, a function that requires its 5'Nucleotidase activity. Defects in NT5E are the cause of calcification of joints and arteries (CAJA). The recombinant CD73 lacking GPI anchor is secreted as a monomer.