产品中心
-
产品货号
产品名称
规格
销售价
会员价
货期
产地
订购
-
C404
Recombinant Human B7-2/CD86
10ug
400
360
现货
国产
-
C404
Recombinant Human B7-2/CD86
50ug
1200
1080
现货
国产
-
C404
Recombinant Human B7-2/CD86
500ug
8960
8064
现货
国产
-
C404
Recombinant Human B7-2/CD86
1mg
12800
11520
现货
国产
-
C404
Recombinant Human CD86/B7-2
10ug
400
360
现货
国产
-
C404
Recombinant Human CD86/B7-2
50ug
1200
1080
现货
国产
-
C404
Recombinant Human CD86/B7-2
500ug
8960
8064
现货
国产
-
C404
Recombinant Human CD86/B7-2
1mg
12800
11520
现货
国产
- 产品简介
- 使用说明
- 相关产品
- 参考文献
- 购买咨询
Catalog# C404 Source HEK293 Description Recombinant Human B7-2/CD86 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (A24-P247) of Human CD86 fused with a polyhistidine tag at the C-terminus. Names T-Lymphocyte Activation Antigen CD86, Activation B7-2 Antigen, B70, BU63, CTLA-4 Counter-Receptor B7.2, FUN-1, CD86, CD28LG2, B7-2 Accession # P42081 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence APLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSF DSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYI NLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGIMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFC ILETDKTRLLSSPFSIELEDPQPPPDHIPVDVHHHHHHBackground The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8， human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.