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CF12
Recombinant Human CDK4/Cyclin-dependent kinase 4
10ug
840
756
现货
国产
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CF12
Recombinant Human CDK4/Cyclin-dependent kinase 4
50ug
2520
2268
现货
国产
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CF12
Recombinant Human CDK4/Cyclin-dependent kinase 4
500ug
13440
12096
现货
国产
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CF12
Recombinant Human CDK4/Cyclin-dependent kinase 4
1mg
19200
17280
现货
国产
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Catalog# CF12 Source E.coli Description Recombinant Human Cyclin-Dependent Kinase 4/CDK4 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Glu303) of Human CDK4 fused with a 6His tag at the N-terminus. Names Cyclin-Dependent Kinase 4, Cell Division Protein Kinase 4, PSK-J3, CDK4 Accession # P11802 Formulation Supplied as a 0.2 μm filtered solution of PBS, pH 7.4 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSMATSRYEPVAEIGVGAYGTVYKARDPHSGHF VALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV DQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL ARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI FDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ HSYLHKDEGNPEBackground Cyclin-Dependent Kinase 4 (CDK4) is a member of the CMGC Ser/Thr protein kinase family and CDC2/CDKX subfamily. CDK4 is a component of Cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. These complexes are major integrators of various mitogenenic and antimitogenic signals. It is shown that CDK4 is responsible for the phosphorylation of retinoblastoma gene product (Rb). Defects in CDK4 are a cause of susceptibility to cutaneous Malignant Melanoma Type 3.