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CF11
Recombinant Human CDK6/Cyclin-dependent kinase 6
10ug
1200
1080
现货
国产
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CF11
Recombinant Human CDK6/Cyclin-dependent kinase 6
50ug
3520
3168
现货
国产
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CF11
Recombinant Human CDK6/Cyclin-dependent kinase 6
500ug
13440
12096
现货
国产
-
CF11
Recombinant Human CDK6/Cyclin-dependent kinase 6
1mg
19200
17280
现货
国产
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Catalog# CF11 Source E.coli Description Recombinant Human Cyclin-Dependent Kinase 6/CDK6 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ala326) of Human CDK6 fused with a 6His tag at the N-terminus. Names Cyclin-Dependent Kinase 6, Cell Division Protein Kinase 6, Serine/Threonine-Protein Kinase PLSTIRE, CDK6, CDKN6 Accession # Q00534 Formulation Supplied as a 0.2 μm filtered solution of 50mM Tris, 100mM NaCl, 20% Glycerol, 5mM DTT, pH 8.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Biological Activity IN STOCK Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MGSSHHHHHHSSGLVPRGSHMEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV RVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLD KVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER CKENLDSHLPPSQNTSELNTABackground Cyclin-Dependent Kinase 6 (CDK6 belongs to the CMGC Ser/Thr protein kinase family and CDC2/CDKX subfamily. CDK6 is expressed in many tissues and contains one protein kinase domain. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Mutations and overexpression of CDK6, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.