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C842
Recombinant Human CDK7/Cyclin-dependent kinase 7
10ug
1200
1080
现货
国产
-
C842
Recombinant Human CDK7/Cyclin-dependent kinase 7
50ug
3520
3168
现货
国产
-
C842
Recombinant Human CDK7/Cyclin-dependent kinase 7
500ug
12320
11088
现货
国产
-
C842
Recombinant Human CDK7/Cyclin-dependent kinase 7
1mg
17600
15840
现货
国产
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Catalog# C842 Source E. coli Description Recombinant Human Cyclin-Dependent Kinase 7/CDK7 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Phe346) of Human CDK7 fused with a 6His tag at the N-terminus. Names Cyclin-Dependent Kinase 7, 39 kDa Protein Kinase, p39 Mo15, CDK-Activating Kinase 1, Cell Division Protein Kinase 7, Serine/Threonine-Protein Kinase 1, TFIIH Basal Transcription Factor Complex Kinase Subunit, CDK7, CAK, CAK1, CDKN7, MO15, STK1 Accession # P50613 Formulation Lyophilized from a 0.2 μm filtered solution of 50mM PB,100mM NaCl,5mM DTT,20%Glycerol pH7.0 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence MGSSHHHHHHSSGLVPRGSHMALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKL GHRSEAKDGINRTAL REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVL TPSHIKAYMLM TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQV VTRWYRA PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW PDM CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIFBackground Cyclin-dependent kinase 7 (CDK7) belongs to the CMGC Ser/Thr superfamily, CDK7 colocalizes with PRKCI in the cytoplasm and nucleus, translocating from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides. As a serine/threonine kinase CDK7 is involved in cell cycle control and RNA polymerase II-mediated RNA transcription. In addition, CDK7 is the catalytic subunit of the CDK-activating kinase complex, which phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11.