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CD01

Recombinant Human CDNF/Cerebral dopamine neurotrophic factor

10ug

760

684

现货

国产

CD01

Recombinant Human CDNF/Cerebral dopamine neurotrophic factor

50ug

2000

1800

现货

国产

CD01

Recombinant Human CDNF/Cerebral dopamine neurotrophic factor

500ug

12320

11088

现货

国产

CD01

Recombinant Human CDNF/Cerebral dopamine neurotrophic factor

1mg

17600

15840

现货

国产

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  • Catalog# CD01
    Source Human Cells
    Description Recombinant Human Cerebral dopamine neurotrophic factor/CDNF is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Gln25­Leu187) of Human CDNF fused with a polyhistidine tag at the C-terminus.
    Names Cerebral dopamine neurotrophic factor, ARMET-like protein 1, Conserved dopamine neurotrophic factor, ARMETL1
    Accession # Q49AH0
    Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4
    Shipping The product is shipped at ambient temperature.
    Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    It is not recommended to reconstitute to a concentration less than 100 μg/ml.
    Dissolve the lyophilized protein in 1X PBS.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
    Endotoxin Less than 0.1 ng/µg (1 IEU/µg).
    Amino Acid Sequence
    QGQEAGGRPGADCEVCKEFLNRFYKSLIDRGVNFSLDTIEKELISFCLDTKGKENRLCYYLGATK DAATKILSEVTRPMSVHMPAMKICEKLKKLDSQICELKYEKTLDLASVDLRKMRVAELKQILHSW GEECRACAEKTDYVNLIQELAPKYAATHPKTELHHHHHH
    Background erebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues.It is belongs to the ARMET family. CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease, suggesting that CDNF might be beneficial for the treatment of Parkinson's disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex, hippocampus, substantia nigra, striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.