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CE53
Recombinant Human Checkpoint protein HUS1/HUS1
10ug
1200
1080
现货
国产
-
CE53
Recombinant Human Checkpoint protein HUS1/HUS1
50ug
3520
3168
现货
国产
-
CE53
Recombinant Human Checkpoint protein HUS1/HUS1
500ug
12320
11088
现货
国产
-
CE53
Recombinant Human Checkpoint protein HUS1/HUS1
1mg
17600
15840
现货
国产
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Catalog# CE53 Source E.coli Description Recombinant Human Checkpoint Protein HUS1/HUS1 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Ser280) of Human HUS1 fused with a 6His tag at the N-terminus. Names Checkpoint Protein HUS1, hHUS1, HUS1 Accession # O60921 Formulation Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 40% Glycerol, pH 8.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Biological Activity IN STOCK Purity Greater than 95% as determined by reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MGSSHHHHHHSSGLVPRGSHMKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCD KLANGGVSMWCELEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHF PCLTVSVELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKN ISNHLVIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKLLQF LAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALSVEHHHHHHBackground Checkpoint protein HUS1 is a member of the HUS1 family, members of which are shuttled between the nucleus and cytoplasm. HUS1 is expressed in many tissues. HUS1 is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex involved in arresting the cell cycle in response to DNA damage. DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. HUS1 binds with Rad9 and Rad1 to form the 9-1-1 (RAD9-RAD1-HUS1) complex, which localizes to DNA lesions and promotes DNA damage signaling and repair or apoptosis and cell cycle arrest.