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CE53

Recombinant Human Checkpoint protein HUS1/HUS1

10ug

1200

1080

现货

国产

CE53

Recombinant Human Checkpoint protein HUS1/HUS1

50ug

3520

3168

现货

国产

CE53

Recombinant Human Checkpoint protein HUS1/HUS1

500ug

12320

11088

现货

国产

CE53

Recombinant Human Checkpoint protein HUS1/HUS1

1mg

17600

15840

现货

国产

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  • Catalog# CE53
    Source E.coli
    Description Recombinant Human Checkpoint Protein HUS1/HUS1 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Ser280) of Human HUS1 fused with a 6His tag at the N-terminus.
    Names Checkpoint Protein HUS1, hHUS1, HUS1
    Accession # O60921
    Formulation Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 40% Glycerol, pH 8.0
    Shipping The product is shipped on dry ice/ice packs.
    Storage Store at < -20°C, stable for 6 months after receipt.
    Please minimize freeze-thaw cycles.
    Biological Activity IN STOCK
    Purity Greater than 95% as determined by reducing SDS-PAGE.
    Endotoxin Less than 0.1 ng/µg (1 IEU/µg).
    Amino Acid Sequence
    MGSSHHHHHHSSGLVPRGSHMKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCD KLANGGVSMWCELEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHF PCLTVSVELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKN ISNHLVIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKLLQF LAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALSVEHHHHHH
    Background Checkpoint protein HUS1 is a member of the HUS1 family, members of which are shuttled between the nucleus and cytoplasm. HUS1 is expressed in many tissues. HUS1 is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex involved in arresting the cell cycle in response to DNA damage. DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. HUS1 binds with Rad9 and Rad1 to form the 9-1-1 (RAD9-RAD1-HUS1) complex, which localizes to DNA lesions and promotes DNA damage signaling and repair or apoptosis and cell cycle arrest.