产品中心

产品货号

产品名称

规格

销售价

会员价

货期

产地

订购

CE14

Recombinant Human CLIC4/Chloride intracellular channel protein 4

10ug

1200

1080

现货

国产

CE14

Recombinant Human CLIC4/Chloride intracellular channel protein 4

50ug

3520

3168

现货

国产

CE14

Recombinant Human CLIC4/Chloride intracellular channel protein 4

500ug

12320

11088

现货

国产

CE14

Recombinant Human CLIC4/Chloride intracellular channel protein 4

1mg

17600

15840

现货

国产

  • 产品简介
  • 使用说明
  • 相关产品
  • 参考文献
  • 购买咨询
  • Catalog# CE14
    Source E.coli
    Description Recombinant Human Chloride Intracellular Channel Protein 4/CLIC4 produced by E. coli expression system. The target protein is expressed with sequence (Met1-Lys253) of Human CLIC4 fused with a 6His tag at the N-terminus.
    Names Chloride Intracellular Channel Protein 4, Intracellular Chloride Ion Channel Protein p64H1, CLIC4
    Accession # Q9Y696
    Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, pH 8.0
    Shipping The product is shipped on dry ice/ice packs.
    Storage Store at < -20°C, stable for 6 months after receipt.
    Please minimize freeze-thaw cycles.
    Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
    Endotoxin Less than 0.1 ng/μg (1 IEU/μg).
    Amino Acid Sequence
    MGSSHHHHHHSSGLVPRGSHMALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMIL WLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPK HPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFST RKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEV EIAYSDVAKRLTK
    Background Chloride Intracellular Channel Protein 4 (CLIC4) is a 253 amino acid single-pass membrane protein that localizes to both the nucleus and the cytoplasm and contains one GST C-terminal domain. CLIC4 is expressed in various tissues and exhibits an intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). CLIC4 acts as a monomer which is able to form selective ion channels in target proteins, thus facilitating the transport of chloride and other ions. CLIC4 is believed to have a role in apoptosis and is able to translocate to the nucleus under stress conditions. CLIC4 has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis.