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C595
Recombinant Human Corticotropin-releasing factor-binding protein/CRHBP
10ug
840
756
现货
国产
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C595
Recombinant Human Corticotropin-releasing factor-binding protein/CRHBP
50ug
2520
2268
现货
国产
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C595
Recombinant Human Corticotropin-releasing factor-binding protein/CRHBP
500ug
12320
11088
现货
国产
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C595
Recombinant Human Corticotropin-releasing factor-binding protein/CRHBP
1mg
17600
15840
现货
国产
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Catalog# C595 Source HEK293 Description Recombinant Human Corticotropin-Releasing Factor-Binding Protein/CRHBP is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Tyr25-Leu322) of Human CRHBP fused with a polyhistidine tag at the C-terminus. Names Corticotropin-Releasing Factor-Binding Protein, CRF-BP, CRF-Binding Protein, Corticotropin-Releasing Hormone-Binding Protein, CRH-BP, CRHBP, CRFBP Accession # P24387 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mm NaCl, pH 7.5 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence YLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEP EEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQ NVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISD LTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRM VSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGLVDHHHHHHBackground Corticotropin-Releasing Factor-Binding Protein (CRHBP) is a 37 kDa secreted glycoprotein that binds both CRH and urocortin in a 42 kDa extracellular complex. The molecule is approximately 300 amino acids in length and demonstrates five intrachain disulfide bonds. Difference between CRHBP from different species exist, human CRHBP is found in plasma while rodent and sheep CRHBP is limited to neuroendocrine tissues. CRHBP may inactivate CRH and may prevent inappropriate pituitary-adrenal stimulation in pregnancy. CRHBP is presumed to either sequester CRH, rendering it unavailable to cells or transport it to target tissues. Although CRF-BP concentration in the human peripheral circulation is normally low, it increases throughout pregnancy and fall back rapidly after parturition.