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C316

Recombinant Human CD319/CRACC/SLAMF7

10ug

560

504

现货

国产

C316

Recombinant Human CD319/CRACC/SLAMF7

50ug

1680

1512

现货

国产

C316

Recombinant Human CD319/CRACC/SLAMF7

500ug

12320

11088

现货

国产

C316

Recombinant Human CD319/CRACC/SLAMF7

1mg

17600

15840

现货

国产

C316

Recombinant Human CRACC/SLAMF7/CD319

10ug

560

504

现货

国产

C316

Recombinant Human CRACC/SLAMF7/CD319

50ug

1680

1512

现货

国产

C316

Recombinant Human CRACC/SLAMF7/CD319

500ug

12320

11088

现货

国产

C316

Recombinant Human CRACC/SLAMF7/CD319

1mg

17600

15840

现货

国产

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  • Catalog# C316
    Source HEK293
    Description Recombinant Human SLAM Family Member 7/SLAMF7 produced by transfected human cells is a secreted protein with sequence (Ser23-Ser225) of Human SLAMF7 fused with a polyhistidine tag at the C-terminus.
    Names SLAM Family Member 7, CD2 Subset 1, CD2-Like Receptor-Activating Cytotoxic Cells, CRACC, Membrane Protein FOAP-12, Novel Ly9, Protein 19A, CD319, SLAMF7, CS1
    Accession # Q9NQ25
    Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4
    Shipping The product is shipped at ambient temperature.
    Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    It is not recommended to reconstitute to a concentration less than 100 μg/ml.
    Dissolve the lyophilized protein in 1X PBS.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
    Endotoxin Less than 0.1 ng/µg (1 IEU/µg).
    Amino Acid Sequence
    SGPVKELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPEGGTIIVTQNRNRERVDFPDGG YSLKLSKLKKNDSGIYYVGIYSSSLQQPSTQEYVLHVYEHLSKPKVTMGLQSNKNGTCVTNLTCC MEHGEEDVIYTWKALGQAANESHNGSILPISWRWGESDMTFICVARNPVSRNFSSPILARKLCEG AADDPDSSVDHHHHHH
    Background SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.