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C316
Recombinant Human CD319/CRACC/SLAMF7
10ug
560
504
现货
国产
-
C316
Recombinant Human CD319/CRACC/SLAMF7
50ug
1680
1512
现货
国产
-
C316
Recombinant Human CD319/CRACC/SLAMF7
500ug
12320
11088
现货
国产
-
C316
Recombinant Human CD319/CRACC/SLAMF7
1mg
17600
15840
现货
国产
-
C316
Recombinant Human CRACC/SLAMF7/CD319
10ug
560
504
现货
国产
-
C316
Recombinant Human CRACC/SLAMF7/CD319
50ug
1680
1512
现货
国产
-
C316
Recombinant Human CRACC/SLAMF7/CD319
500ug
12320
11088
现货
国产
-
C316
Recombinant Human CRACC/SLAMF7/CD319
1mg
17600
15840
现货
国产
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Catalog# C316 Source HEK293 Description Recombinant Human SLAM Family Member 7/SLAMF7 produced by transfected human cells is a secreted protein with sequence (Ser23-Ser225) of Human SLAMF7 fused with a polyhistidine tag at the C-terminus. Names SLAM Family Member 7, CD2 Subset 1, CD2-Like Receptor-Activating Cytotoxic Cells, CRACC, Membrane Protein FOAP-12, Novel Ly9, Protein 19A, CD319, SLAMF7, CS1 Accession # Q9NQ25 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence SGPVKELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPEGGTIIVTQNRNRERVDFPDGG YSLKLSKLKKNDSGIYYVGIYSSSLQQPSTQEYVLHVYEHLSKPKVTMGLQSNKNGTCVTNLTCC MEHGEEDVIYTWKALGQAANESHNGSILPISWRWGESDMTFICVARNPVSRNFSSPILARKLCEG AADDPDSSVDHHHHHHBackground SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.