| Catalog# |
C221 |
| Source |
E.coli |
| Description |
Recombinant Human Fatty Acid-Binding Protein 6/FABP6 is produced by our E.. coli expression system. The target protein is expressed with sequence (Ala2-Ala128) of Human FABP6 fused with a His tag at the N-terminus. |
| Names |
Gastrotropin, GT, Fatty Acid-Binding Protein 6, Ileal Lipid-Binding Protein, ILBP, Intestinal 15 kDa Protein, I-15P, Intestinal Bile Acid-Binding Protein, I-BABP, FABP6, ILBP, ILLBP |
| Accession # |
P51161 |
| Formulation |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 0.5mM DTT, 50% Glycerol, pH 8.0 |
| Shipping |
The product is shipped on dry ice/ice packs. |
| Storage |
Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. |
| Purity |
Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin |
Less than 0.1 ng/μg (1 IEU/μg). |
| Amino Acid Sequence |
MGSSHHHHHHSSGLVPRGSHMAFTGKFEMESEKNYDEFMKLLGISSDVIEKAHNFKIVTEVQQDG QDFTWSQHYYGGHTMTNKFTVGKESNIQTMGGKTFKATVQMEGGKLVVNFPNYHQTSEIVGDKLV EVSTIGGVTYERVSKRLA
|
| Background |
Fatty Acid-Binding Protein 6 (FABP6) is cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands which belongs to the calycin superfamily. FABP6 expression is restricted in the small intestine to the ileum where it is involved in the enterohepatic circulation of bile acids. FABP6 forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. FABP6 plays a role in fatty acid uptake, transport, and metabolism. FABP6 stimulates gastric acid and pepsinogen secretion. It seems to be able to bind to bile salts and bilirubins. |
