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C469
Recombinant Human CD89/FCAR
10ug
640
576
现货
国产
-
C469
Recombinant Human CD89/FCAR
50ug
1760
1584
现货
国产
-
C469
Recombinant Human CD89/FCAR
500ug
12320
11088
现货
国产
-
C469
Recombinant Human CD89/FCAR
1mg
17600
15840
现货
国产
-
C469
Recombinant Human FCAR/CD89
10ug
640
576
现货
国产
-
C469
Recombinant Human FCAR/CD89
50ug
1760
1584
现货
国产
-
C469
Recombinant Human FCAR/CD89
500ug
12320
11088
现货
国产
-
C469
Recombinant Human FCAR/CD89
1mg
17600
15840
现货
国产
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Catalog# C469 Source HEK293 Description Recombinant Human Immunoglobulin α Fc Receptor/FCAR produced by transfected human cells is a secreted protein with sequence (Gln22-Asn227) of Human FCAR fused with a polyhistidine tag at the C-terminus. Names Immunoglobulin Alpha Fc Receptor, IgA Fc Receptor, CD89, FCAR Accession # P24071 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence QEGDFPMPFISAKSSPVIPLDGSVKIQCQAIREAYLTQLMIIKNSTYREIGRRLKFWNETDPEFV IDHMDANKAGRYQCQYRIGHYRFRYSDTLELVVTGLYGKPFLSADRGLVLMPGENISLTCSSAHI PFDRFSLAKEGELSLPQHQSGEHPANFSLGPVDLNVSGIYRCYGWYNRSPYLWSFPSNALELVVT DSIHQDYTTQNVDHHHHHHBackground Immunoglobulin α Fc Receptor (IgA Fc Receptor) is a member of the immunoglobulin gene superfamily. It is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens through the charged arginin residue within its transmembrane domain. IgA Fc Receptor binds both IgA1 and IgA2 with similar affinity. The site of interaction between FCAR and IgA was identified in the first extracellular domain of FCAR and the C2/C3 junction of IgA. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. FCAR is also expressed on Kupffer cells in the liver, where it was suggested to provide a second line of defense.