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C444
Recombinant Human CD32b/Fc-gamma RII-b
10ug
640
576
现货
国产
-
C444
Recombinant Human CD32b/Fc-gamma RII-b
50ug
1760
1584
现货
国产
-
C444
Recombinant Human CD32b/Fc-gamma RII-b
500ug
12320
11088
现货
国产
-
C444
Recombinant Human CD32b/Fc-gamma RII-b
1mg
17600
15840
现货
国产
-
C444
Recombinant Human Fc-gamma RII-b/CD32b
10ug
640
576
现货
国产
-
C444
Recombinant Human Fc-gamma RII-b/CD32b
50ug
1760
1584
现货
国产
-
C444
Recombinant Human Fc-gamma RII-b/CD32b
500ug
12320
11088
现货
国产
-
C444
Recombinant Human Fc-gamma RII-b/CD32b
1mg
17600
15840
现货
国产
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Catalog# C444 Source HEK293 Description Recombinant Human FcγRIIB/FCGR2B is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Thr43-Pro217) of Human FCGR2B fused with a polyhistidine tag at the C-terminus. Names Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b, IgG Fc Receptor II-b, CDw32, Fc-Gamma RII-b, Fc-Gamma-RIIb, FcRII-b, CD32, FCGR2B, FCG2, IGFR2 Accession # P31994 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence TPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNND SGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSK KFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPVDHHHHHHBackground FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and delivers an inhibitory signal upon ligand binding. Ligation of FcγRIIB on B cells down-regulates antibody production and in some circumstances may promote apoptosis. Co-ligation of FcγRIIB on dendritic cells inhibits maturation and blocks cell activation. FcγRIIB may also be a target for monoclonal antibody therapy for malignancies. FcγRIIB plays an important negative-regulating role through modulating the signals from activation receptors.