产品中心
-
产品货号
产品名称
规格
销售价
会员价
货期
产地
订购
-
C441
Recombinant Human CD16a/Fc gamma RIIIA
10ug
640
576
现货
国产
-
C441
Recombinant Human CD16a/Fc gamma RIIIA
50ug
1760
1584
现货
国产
-
C441
Recombinant Human CD16a/Fc gamma RIIIA
500ug
12320
11088
现货
国产
-
C441
Recombinant Human CD16a/Fc gamma RIIIA
1mg
17600
15840
现货
国产
-
C441
Recombinant Human Fc-gamma RIIIA/CD16a
10ug
640
576
现货
国产
-
C441
Recombinant Human Fc-gamma RIIIA/CD16a
50ug
1760
1584
现货
国产
-
C441
Recombinant Human Fc-gamma RIIIA/CD16a
500ug
12320
11088
现货
国产
-
C441
Recombinant Human Fc-gamma RIIIA/CD16a
1mg
17600
15840
现货
国产
- 产品简介
- 使用说明
- 相关产品
- 参考文献
- 购买咨询
Catalog# C441 Source HEK293 Description Recombinant Human FcγRIIIA/FCGR3A produced by transfected human cells is a secreted protein with sequence (Gly17-Gln208) of Human FCGR3A with a polyhistidine tag at the C-terminus. Names Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A, CD16a Antigen, Fc-Gamma RIII-Alpha, Fc-Gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc Receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3 Accession # P08637 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence GMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATV DDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGK GRKYFHHNSDFYIPKATLKDSGSYFCRGLVGSKNVSSETVNITITQGLAVSTISSFFPPGYQHHH HHHBackground Receptors for the Fc region of immunoglobin G (FcγR) are divided into three classes and FcγRIII is a multifunctional, low/intermediate affinity receptor. In humans, FcγRIII is expressed as two distinct forms (FcγRIIIA and FcγRIIIB) that are encoded by two different but highly homologous genes in a cell type-specific manner. FcγRIIIB is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas FcγRIIIA is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages. The FcγRIIIA receptor is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. FcγRIIIA has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. Aberrant expression or mutations in this gene is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia. In humans, it is a 50 -70 kD type I transmembrane activating receptor. The FcγRIIIA cDNA encodes 254 amino acid including a 16aa signal sequence, 191 amino acid ECD with two C2-type Ig-like domains, five potential N-glycosylation sites, a 22 amino acid transmembrane sequence and a 25 amino acid cytoplasmic domain. References Kapur R,et al.A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy
PMID:24243971
http://www.ncbi.nlm.nih.gov/pubmed/24243971
