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CG67
Recombinant Human Guanidinoacetate N-methyltransferase/GAMT
10ug
760
684
现货
国产
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CG67
Recombinant Human Guanidinoacetate N-methyltransferase/GAMT
50ug
2280
2052
现货
国产
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CG67
Recombinant Human Guanidinoacetate N-methyltransferase/GAMT
500ug
12320
11088
现货
国产
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CG67
Recombinant Human Guanidinoacetate N-methyltransferase/GAMT
1mg
17600
15840
现货
国产
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Catalog# CG67 Source E.coli Description Recombinant Human Guanidinoacetate N-methyltransferase/GAMT is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Gly236) of Human GAMT fused with a 6His tag at the N-terminus and C-terminus. Names Guanidinoacetate N-methyltransferase, GAMT, PIG2,TP53I2 Accession # Q14353 Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl,1mM DTT,pH 8.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MGSSHHHHHHSSGLVPRGSHMSAPSATPIFAPGENCSPAWGAAPAAYDAADTHLRILGKPVMERW ETPYMHALAAAASSKGGRVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRDWAPRQTHKV IPLKGLWEDVAPTLPDGHFDGILYDTYPLSEETWHTHQFNFIKNHAFRLLKPGGVLTYCNLTSWG ELMKSKYSDITIMFEETQVPALLEAGFRRENIRTEVMALVPPADCRYYAFPQMITPLVTKGLEHH HHHH*Background GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid in brain and body fluids.