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CE23
Recombinant Human Inosine triphosphate pyrophosphatase/ITPA
10ug
1200
1080
现货
国产
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CE23
Recombinant Human Inosine triphosphate pyrophosphatase/ITPA
50ug
3520
3168
现货
国产
-
CE23
Recombinant Human Inosine triphosphate pyrophosphatase/ITPA
500ug
12320
11088
现货
国产
-
CE23
Recombinant Human Inosine triphosphate pyrophosphatase/ITPA
1mg
17600
15840
现货
国产
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Catalog# CE23 Source E.coli Description Recombinant Human Inosine Triphosphate Pyrophosphatase/ITPase is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Ala194) of Human ITPA fused with a 6His tag at the C-terminus. Names Inosine Triphosphate Pyrophosphatase, ITPase, Inosine Triphosphatase, Non-Canonical Purine NTP Pyrophosphatase, Non-Standard Purine NTP Pyrophosphatase, Nucleoside-Triphosphate Diphosphatase, Nucleoside-Triphosphate Pyrophosphatase, NTPase, Putative Oncog Accession # Q9BY32 Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, pH 8.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence MAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEAVRQVQ GPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVR LFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFRALLELQEYFGSLAAL EHHHHHHBackground Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.