产品中心
-
产品货号
产品名称
规格
销售价
会员价
货期
产地
订购
-
C358
Recombinant Human Interferon alpha/beta receptor 1/IFN-α/β R1
10ug
640
576
现货
国产
-
C358
Recombinant Human Interferon alpha/beta receptor 1/IFN-α/β R1
50ug
1760
1584
现货
国产
-
C358
Recombinant Human Interferon alpha/beta receptor 1/IFN-α/β R1
500ug
12320
11088
现货
国产
-
C358
Recombinant Human Interferon alpha/beta receptor 1/IFN-α/β R1
1mg
17600
15840
现货
国产
- 产品简介
- 使用说明
- 相关产品
- 参考文献
- 购买咨询
Catalog# C358 Source HEK293 Description Recombinant Human Interferon-α/β Receptor 1 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Lys28-Lys436) of Human IFNAR1 fused with a polyhistidine tag at the C-terminus. Names Interferon Alpha/Beta Receptor 1, IFN-R-1, IFN-Alpha/Beta Receptor 1, Cytokine Receptor Class-II Member 1, Cytokine Receptor Family 2 Member 1, CRF2-1, Type I Interferon Receptor 1, IFNAR1, IFNAR Accession # P17181 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence KNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNITSTKCNFSSL KLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQIGPPEVHLEAEDKAIVIHISPGTKDSVMWA LDGLSFTYSLVIWKNSSGVEERIENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIK TTVENELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKWKQIPDCENVK TTQCVFPQNVFQKGIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLPPVFNIRSLSDSFHIYIGA PKQSGNTPVIQDYPLIYEIIFWENTSNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNK SSVFSDAVCEKTKPGNTSKLDHHHHHHBackground The Interferon-α/β Receptor 1 (IFN-α/β R1) is a receptor which binds Type I Interferons including Interferon-α and -β. It is a cell surface receptor and heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. IFN-α/β R1, in association with IFN-α/β R2, is required for propagating antiviral signal transduction triggered by IFN-α and IFN-β. IFN-α/β R1 interacts very weakly or not at all with type 1 interferons and does not stably interact with IFN-α/β R2. Ligands associate with IFN-α/β R2, and this complex subsequently forms a stable ternary assembly with IFN-α/β R1. IFN-α/β R1 also associates with IFN-γ R2 even in the absence of IFN-γ stimulation. Human IFN-α/β R1 contains a nuclear localization signal in its extracellular domain that is required for receptor translocation to the nucleus following interaction with ligand. Interferon stimulation results in an immunologic response that is especially associated with viruses.