产品中心
-
产品货号
产品名称
规格
销售价
会员价
货期
产地
订购
-
C468
Recombinant Human F11 Receptor/F11R/JAM-A
10ug
840
756
现货
国产
-
C468
Recombinant Human F11 Receptor/F11R/JAM-A
50ug
2520
2268
现货
国产
-
C468
Recombinant Human F11 Receptor/F11R/JAM-A
500ug
12320
11088
现货
国产
-
C468
Recombinant Human F11 Receptor/F11R/JAM-A
1mg
17600
15840
现货
国产
-
C468
Recombinant Human JAM-A/F11 Receptor/F11R
10ug
840
756
现货
国产
-
C468
Recombinant Human JAM-A/F11 Receptor/F11R
50ug
2520
2268
现货
国产
-
C468
Recombinant Human JAM-A/F11 Receptor/F11R
500ug
12320
11088
现货
国产
-
C468
Recombinant Human JAM-A/F11 Receptor/F11R
1mg
17600
15840
现货
国产
- 产品简介
- 使用说明
- 相关产品
- 参考文献
- 购买咨询
Catalog# C468 Source HEK293 Description Recombinant Human Junctional Adhesion Molecule A/JAM-A produced by transfected human cells is a secreted protein with sequence (Ser28-Val238) of Human JAM-A fused with a polyhistidine tag at the C-terminus. Names Junctional Adhesion Molecule A, JAM-A, Junctional Adhesion Molecule 1, JAM-1, Platelet F11 Receptor, Platelet Adhesion Molecule 1, PAM-1, CD321, F11R, JAM1, JCAM Accession # Q9Y624 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 50mM NaCl, 100mM Glycine, pH 7.5 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence SVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPT GITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQD GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPM TSNAVRMEAVERNVGVDHHHHHHBackground Junctional Adhesion Molecule A (JAM-A) is a single-pass type I membrane protein that belongs to the immunoglobulin superfamily. JAM-A contains 2 Ig-like V-type (immunoglobulin-like) domains and Interacts with the ninth PDZ domain. JAM-A is localized to the tight junctions of both epithelial and endothelial cells. JAM-A seems to be involved in epithelial tight junction formation. JAM-A appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM-A, thereby preventing tight junction assembly. JAM-A plays a role in regulating monocyte transmigration involved in regulating integrity of the epithelial barrier. In the case of orthoreovirus infection, JAM-A serves as receptor for the virus.