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C371
Recombinant Human Legumain/Asparaginyl Endopeptidase
10ug
1200
1080
现货
国产
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C371
Recombinant Human Legumain/Asparaginyl Endopeptidase
50ug
3520
3168
现货
国产
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C371
Recombinant Human Legumain/Asparaginyl Endopeptidase
500ug
12320
11088
现货
国产
-
C371
Recombinant Human Legumain/Asparaginyl Endopeptidase
1mg
17600
15840
现货
国产
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Catalog# C371 Source HEK293 Description Recombinant Human Legumain produced by transfected human cells is a secreted protein with sequence (Ile18-Tyr433) of Human Legumain fused with a polyhistidine tag at the C-terminus. Names Legumain, Asparaginyl Endopeptidase, Protease Cysteine 1, LGMN, PRSC1 Accession # Q99538 Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence IPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIAYSEDNPT PGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVKGIGSGKVLKSGPQDHVFIYFTD HGSTGILVFPNEDLHVKDLNETIHYMYKHKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANP RESSYACYYDEKRSTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTIST MKVMQFQGMKRKASSPVPLPPVTHLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDAR HLIEKSVRKIVSLLAASEAEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYV LVNLCEKPYPLHRIKLSMDHVCLGHYVDHHHHHHBackground Legumain is a lysosomal cysteine protease which is a member of the peptidase C13 family. Though it is found in many tissues, it is highly expressed in the kidney, heart, and placenta. Legumain has a strict specificity for hydrolysis of asparaginyl bonds and can also cleave aspartyl bonds slowly, especially under acidic conditions. Over-expression Legumain in tumors is significant for invasion and metastasis. In addition, Legumain may be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system and negative regulation of neuron apoptosis.