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CG84
Recombinant Human LIM and cysteine-rich domains protein 1/LMCD1/Dyxin
10ug
1200
1080
现货
国产
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CG84
Recombinant Human LIM and cysteine-rich domains protein 1/LMCD1/Dyxin
50ug
3520
3168
现货
国产
-
CG84
Recombinant Human LIM and cysteine-rich domains protein 1/LMCD1/Dyxin
500ug
13440
12096
现货
国产
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CG84
Recombinant Human LIM and cysteine-rich domains protein 1/LMCD1/Dyxin
1mg
19200
17280
现货
国产
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Catalog# CG84 Source E.coli Description Recombinant Human LIM and cysteine-rich domains protein 1/LMCD1/Dyxin is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ser365) of Human LMCD1 fused with a 6His tag at the N-terminus and a 6His tag at the C-terminus. Names LIM and cysteine-rich domains protein 1, LMCD1, Dyxin Accession # Q9NZU5 Formulation Supplied as a 0.2 μm filtered solution of PBS, pH 7.4 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MGSSHHHHHHSSGLVPRGSHMAKVAKDLNPGVKKMSLGQLQSARGVACLGCKGTCSGFEPHSWRK ICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKD PTFDTITYEWAPPGVTQKLGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLL ENELKLMEEFVKQYKSEALGVGEVALPGQGGLPKEEGKQQEKPEGAETTAATTNGSLSDPSKEVE YVCELCKGAAPPDSPVVYSDRAGYNKQWHPTCFVCAKCSEPLVDLIYFWKDGAPWCGRHYCESLR PRCSGCDEIIFAEDYQRVEDLAWHRKHFVCEGCEQLLSGRAYIVTKGQLLCPTCSKSKRSLEHHH HHHBackground LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.