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CD98
Recombinant Human Lipocalin-2/LCN2/p25/NGAL
10ug
640
576
现货
国产
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CD98
Recombinant Human Lipocalin-2/LCN2/p25/NGAL
50ug
2000
1800
现货
国产
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CD98
Recombinant Human Lipocalin-2/LCN2/p25/NGAL
500ug
12320
11088
现货
国产
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CD98
Recombinant Human Lipocalin-2/LCN2/p25/NGAL
1mg
17600
15840
现货
国产
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Catalog# CD98 Source HEK293 Description Recombinant Human LCN2 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Gln21-Gly198) of Human LCN2 fused with a polyhistidine tag at the C-terminus. Names Accession # P80188 Formulation Supplied as a 0.2 μm filtered solution of PBS, 50% glycerol,pH7.4 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence QDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYN VTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNR EYFKITLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDGVDHHHHHHBackground LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. LCN2 binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. LCN2 is involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. LCN2 is involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.