产品中心
-
产品货号
产品名称
规格
销售价
会员价
货期
产地
订购
-
C375
Recombinant Human MMP-12/Macrophage metalloelastase
10ug
1200
1080
现货
国产
-
C375
Recombinant Human MMP-12/Macrophage metalloelastase
50ug
3520
3168
现货
国产
-
C375
Recombinant Human MMP-12/Macrophage metalloelastase
500ug
12320
11088
现货
国产
-
C375
Recombinant Human MMP-12/Macrophage metalloelastase
1mg
17600
15840
现货
国产
- 产品简介
- 使用说明
- 相关产品
- 参考文献
- 购买咨询
Catalog# C375 Source Human Cells Description Recombinant Human Matrix Metalloproteinase-12/MMP-12 produced by transfected human cells is a secreted protein with sequence (Leu17-Cys470) of Human MMP-12 fused with a polyhistidine tag at the C-terminus. Names Macrophage Metalloelastase, MME, Macrophage Elastase, ME, hME, Matrix Metalloproteinase-12, MMP-12, MMP12, HME Accession # P39900 Formulation Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 0.05% Brij35, pH 5.5 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Biological Activity IN STOCK Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence LPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDT STLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTP LKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTN LFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDN SEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEAR NQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDER RQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGCV DHHHHHHBackground Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endo-peptidases which degrade components of the extracellular matrix (ECM). MMP-12 (macrophage elastase) is found in macrophages and its expression can be induced by cytokines. MMP 12 plays essential roles in various physiological processes and pathological processes. MMP-12 is responsible for cleavage of plasminogen to angiotensin, which has an angiostatic effect. It may be part in tissue injury and remodeling and has significant elastolytic activity. MMP-12 is related to the pathogenesis of aortic aneurysms and in the development of pulmonary emphysemaMMP-12 is a potent proinflammatory and oncogenic molecule MMP-12 up-regulation plays a critical role in emphysema to lung cancer transition that is facilitated by inflammation.