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C440
Recombinant Human CD112/Nectin-2
10ug
640
576
现货
国产
-
C440
Recombinant Human CD112/Nectin-2
50ug
1760
1584
现货
国产
-
C440
Recombinant Human CD112/Nectin-2
500ug
12320
11088
现货
国产
-
C440
Recombinant Human CD112/Nectin-2
1mg
17600
15840
现货
国产
-
C440
Recombinant Human Nectin-2/CD112
10ug
640
576
现货
国产
-
C440
Recombinant Human Nectin-2/CD112
50ug
1760
1584
现货
国产
-
C440
Recombinant Human Nectin-2/CD112
500ug
12320
11088
现货
国产
-
C440
Recombinant Human Nectin-2/CD112
1mg
17600
15840
现货
国产
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Catalog# C440 Source HEK293 Description Recombinant Human Poliovirus Receptor-Related Protein 2/PVRL2 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Gln32-Leu360) of Human CD112 fused with a polyhistidine tag at the C-terminus. Names Poliovirus Receptor-Related Protein 2, Herpes Virus Entry Mediator B, Herpesvirus Entry Mediator B, HveB, Nectin-2, CD112, PVRL2, HVEB, PRR2 Accession # Q92692 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence QDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSP KPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAK PKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLV PSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEP TGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRD VGPLVDHHHHHHBackground CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens junctions, and exists on neurons, endothelial cells,epithelial cells and fibroblasts. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 mediates cytotoxicity and cytokine secretion by T and NK cells. The costimulatory responses may be a critical component in allergic reactions and may therefore become targets for anti-allergic therapy.