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C634
Recombinant Human Neuroendocrine protein 7B2/SCG5
10ug
840
756
现货
国产
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C634
Recombinant Human Neuroendocrine protein 7B2/SCG5
50ug
2520
2268
现货
国产
-
C634
Recombinant Human Neuroendocrine protein 7B2/SCG5
500ug
12320
11088
现货
国产
-
C634
Recombinant Human Neuroendocrine protein 7B2/SCG5
1mg
17600
15840
现货
国产
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Catalog# C634 Source Human Cells Description Recombinant Human Secretogranin-5/SCG5 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Tyr27-Glu212) of Human SCG5 fused with a polyhistidine tag at the C-terminus. Names Neuroendocrine Protein 7B2, Pituitary Polypeptide, Secretogranin V, Secretogranin-5, Secretory Granule Endocrine Protein I, SCG5, SGNE1 Accession # P05408 Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, 10% Glycerol, pH 8.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence YSPRTPDRVSEADIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNI PNIVAELTGDNIPKDFSEDQGYPDPPNPCPVGKTADDGCLENTPDTAEFSREFQLHQHLSDPEHD YPGLGKWNKKLLYEKMKGGERRKRRSVNPYLQGQRLDNVVAKKSVPHFSDEDKDPEVDHHHHHHBackground Secretogranin-5 (SCG5) is a single non-glycosylated polypeptide that is a member of the 7B2 family. SCG5 is widely distributed in neuroendocrine tissues. SCG5 binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. It functions as a chaperone protein for the proprotein convertase PC2, preventing its premature activation in the regulated secretory pathway. It is also required for cleavage of PCSK2 but does not appear to be involved in its folding. It plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.