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CF53

Recombinant Human ER beta/NR3A2

10ug

1200

1080

现货

国产

CF53

Recombinant Human ER beta/NR3A2

50ug

3520

3168

现货

国产

CF53

Recombinant Human ER beta/NR3A2

500ug

13440

12096

现货

国产

CF53

Recombinant Human ER beta/NR3A2

1mg

19200

17280

现货

国产

CF53

Recombinant Human NR3A2/ER beta

10ug

1200

1080

现货

国产

CF53

Recombinant Human NR3A2/ER beta

50ug

3520

3168

现货

国产

CF53

Recombinant Human NR3A2/ER beta

500ug

13440

12096

现货

国产

CF53

Recombinant Human NR3A2/ER beta

1mg

19200

17280

现货

国产

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  • Catalog# CF53
    Source E.coli
    Description Recombinant Human Estrogen Receptor Beta/ESR2 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ala323) of Human ESR2 fused with a 6His tag at the N-terminus.
    Names Estrogen Receptor Beta, ER-Beta, Nuclear Receptor Subfamily 3 Group A Member 2, ESR2, ESTRB, NR3A2
    Accession # Q92731-3
    Formulation Lyophilized from a 0.2 μm filtered solution of 50mM TrisHCl,pH8.0
    Shipping The product is shipped at ambient temperature.
    Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    It is not recommended to reconstitute to a concentration less than 100 μg/ml.
    Dissolve the lyophilized protein in 1X PBS.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Biological Activity IN STOCK
    Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
    Endotoxin Less than 0.1 ng/µg (1 IEU/µg).
    Amino Acid Sequence
    MGSSHHHHHHSSGLVPRGSHMDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPA MTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEA RSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKR SIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKE LVHMISWAKKIPGMRGNA
    Background Estrogen Receptor Beta (ESR2) is a nuclear protein that belongs to the nuclear hormone receptor family of NR3 subfamily. It contains one nuclear receptor DNA-binding domain and is expressed in many tissues at a lower level. ESR2 is a nuclear hormone receptor. It binds estrogens with an affinity similar to that of ESR1 and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.