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C288
Recombinant Human p27/Kip1/Cyclin-dependent kinase inhibitor 1B/CDKN1B
10ug
1200
1080
现货
国产
-
C288
Recombinant Human p27/Kip1/Cyclin-dependent kinase inhibitor 1B/CDKN1B
50ug
3520
3168
现货
国产
-
C288
Recombinant Human p27/Kip1/Cyclin-dependent kinase inhibitor 1B/CDKN1B
500ug
12320
11088
现货
国产
-
C288
Recombinant Human p27/Kip1/Cyclin-dependent kinase inhibitor 1B/CDKN1B
1mg
17600
15840
现货
国产
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Catalog# C288 Source E.coli Description Recombinant Human Cyclin-Dependent Kinase Inhibitor 1B/CDKN1B is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Thr198) of Human CDKN1B fused with a 6His tag at the N-terminus. Names Cyclin-Dependent Kinase Inhibitor 1B, Cyclin-Dependent Kinase Inhibitor p27, p27Kip1, CDKN1B, KIP1 Accession # P46527 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence MGSSHHHHHHSSGLVPRGSHMSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDL EKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDGS GSRPAAPLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVS DGSPNAGSVEQTPKKPGLRRRQTBackground Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an activator of Cyclin Type D-CDK4 complexes depending on its phosphorylation state and stoichometry.