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CD91
Recombinant Human PDCD1/Programmed cell death protein 1
10ug
760
684
现货
国产
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CD91
Recombinant Human PDCD1/Programmed cell death protein 1
50ug
2000
1800
现货
国产
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CD91
Recombinant Human PDCD1/Programmed cell death protein 1
500ug
12320
11088
现货
国产
-
CD91
Recombinant Human PDCD1/Programmed cell death protein 1
1mg
17600
15840
现货
国产
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Catalog# CD91 Source HEK293 Description Recombinant Recombinant Human Programmed cell death protein 1/PD-1/PDCD1/CD279 is produced by our mammalian expression system in human cells. The human PD-1 protein is expressed with sequence (Leu25-Gln167) of human PDCD1 fused with a polyhistidine tag at the C-terminus. Names Programmed cell death protein 1, hPD-1, PDCD1, CD279, PD1, PD-1 Accession # Q15116 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence LDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQP GQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTA HPSPSPRPAGQFQHHHHHHBackground Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.