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CF65
Recombinant Human PEA15/PED/Astrocytic phosphoprotein PEA-15
10ug
840
756
现货
国产
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CF65
Recombinant Human PEA15/PED/Astrocytic phosphoprotein PEA-15
50ug
2520
2268
现货
国产
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CF65
Recombinant Human PEA15/PED/Astrocytic phosphoprotein PEA-15
500ug
12320
11088
现货
国产
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CF65
Recombinant Human PEA15/PED/Astrocytic phosphoprotein PEA-15
1mg
17600
15840
现货
国产
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Catalog# CF65 Source E.coli Description Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ala130) of Human PEA15. Names Astrocytic Phosphoprotein PEA-15, 15 kDa Phosphoprotein Enriched in Astrocytes, Phosphoprotein Enriched in Diabetes, PED, PEA15 Accession # Q15121 Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence GSHMAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSY IEHIFEISRRPDLLTMVVDYRTRVLKISEEDELDTKLTRIPSAKKYKDIIRQPSEEEIIKLAPPP KKABackground Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.