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C921
Recombinant Human PI4KB/Phosphatidylinositol 4-kinase beta
10ug
1200
1080
现货
国产
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C921
Recombinant Human PI4KB/Phosphatidylinositol 4-kinase beta
50ug
3520
3168
现货
国产
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C921
Recombinant Human PI4KB/Phosphatidylinositol 4-kinase beta
500ug
12320
11088
现货
国产
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C921
Recombinant Human PI4KB/Phosphatidylinositol 4-kinase beta
1mg
17600
15840
现货
国产
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Catalog# C921 Source Human Cells Description Recombinant Human Phosphatidylinositol 4-Kinase β/PI4KB is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Met1-Met801) of Human PI4KB fused with a polyhistidine tag at the C-terminus. Names Phosphatidylinositol 4-Kinase Beta, PI4K-Beta, PI4KBeta, PtdIns 4-Kinase Beta, NPIK, PI4K92, PI4KB, PIK4CB Accession # Q9UBF8-2 Formulation Supplied as a 0.2 μm filtered solution of 25mM Tris.HCl,100mM glycine,10%glycerol,pH7.3 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGG VAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWL LRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIK PYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPA PDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEPVRLAPEREFIKSLMAIGKRLA TLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLE CENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVE LPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKE PWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKI LVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCY LLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYK MLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDG SMRSITTKLYDGFQYLTNGIMVDHHHHHHBackground Phosphatidylinositol 4-Kinase β (PI4KB) belongs to the PI3/PI4-kinase family and Type III PI4K subfamily. PI4KB contains one PI3K/PI4K domain and one PIK helical domain. It is highly expressed in heart, skeletal muscle, pancreas, testis and ovary,; it is lowly expressed in liver tissue. PI4KB kinase activity can be inhibited by wortmannin, and increased by interacting with NCS1/FREQ. PI4KB phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). In addition, PI4KB may regulate Golgi disintegration/reorganization during mitosis.