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C165
Recombinant Human Protein kinase C epsilon type/PKCE
10ug
840
756
现货
国产
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C165
Recombinant Human Protein kinase C epsilon type/PKCE
50ug
2520
2268
现货
国产
-
C165
Recombinant Human Protein kinase C epsilon type/PKCE
500ug
12320
11088
现货
国产
-
C165
Recombinant Human Protein kinase C epsilon type/PKCE
1mg
17600
15840
现货
国产
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Catalog# C165 Source E.coli Description Recombinant Human PKC ε is produced with our E. coli expression system. The target protein is expressed with sequence (Gln580-Pro737) of Human PRKCE. Names Protein Kinase C Epsilon Type, nPKC-Epsilon, PRKCE, PKCE Accession # Q02156 Formulation Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 1mM DTT, pH 7.4 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence MQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMT KNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPV LTLVDEAIVKQINQEEFKGFSYFGEDLMPLEHHHHHHBackground Protein Kinase C Epsilon type is a member of the serine- and threonine-specific protein kinase family that can be activated by calcium and the second messenger diacylglycerol. Protein Kinase C Epsilon contains these domains: one AGC-kinase C-terminal domain, one C2 domain, one protein kinase domain and two phorbol-ester/DAG-type zinc fingers. Protein Kinase C Epsilon phosphorylate a variety of protein targets and has been identified to participate in diverse cellular signaling pathways. It has many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Protein Kinase C Epsilon also serves as the receptor for phorbol esters, a class of tumor promoters. References Zhang KL,et al.Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas
PMID:24012640
http://www.ncbi.nlm.nih.gov/pubmed/24012640