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C162
Recombinant Human Protein phosphatase 1 regulatory subunit 14A/CPI-17
10ug
840
756
现货
国产
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C162
Recombinant Human Protein phosphatase 1 regulatory subunit 14A/CPI-17
50ug
2520
2268
现货
国产
-
C162
Recombinant Human Protein phosphatase 1 regulatory subunit 14A/CPI-17
500ug
12320
11088
现货
国产
-
C162
Recombinant Human Protein phosphatase 1 regulatory subunit 14A/CPI-17
1mg
17600
15840
现货
国产
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Catalog# C162 Source E.coli Description Recombinant Human Protein Phosphatase 1 Regulatory Subunit 14A/PPP1R14A is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Pro147) of Human PPP1R14A. Names Protein Phosphatase 1 Regulatory Subunit 14A, 17 kDa PKC-Potentiated Inhibitory Protein of PP1, Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa, CPI-17, PPP1R14A, CPI17, PPP1INL Accession # Q96A00 Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 0.2mM EDTA, 1mM DTT, 10% Glycerol, pH 8.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence MAAQRLGKRVLSKLQSPSRARGPGGSPGGLQKRHARVTVKYDRRELQRRLDVEKWIDGRLEELYR GMEADMPDEINIDELLELESEEERSRKIQGLLKSCGKPVEDFIQELLAKLQGLHRQPGLRQPSPS HDGSLSPLQDRARTAHPLEHHHHHHBackground Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition, inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.