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CG92
Recombinant Human TNFSF10/TRAIL/APO-2L(C-polyHis)
10ug
360
324
现货
国产
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CG92
Recombinant Human TNFSF10/TRAIL/APO-2L(C-polyHis)
50ug
840
756
现货
国产
-
CG92
Recombinant Human TNFSF10/TRAIL/APO-2L(C-polyHis)
500ug
8960
8064
现货
国产
-
CG92
Recombinant Human TNFSF10/TRAIL/APO-2L(C-polyHis)
1mg
12800
11520
现货
国产
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Catalog# CG92 Source E.coli Description Recombinant Human Tumor Necrosis Factor Ligand Superfamily Member 10/TNFSF10 is produced with our E. coli expression system. The target protein is expressed with sequence (Val114-Gly281) of Human TNFSF10 fused with a 6His tag at the C-terminus. Names Tumor Necrosis Factor Ligand Superfamily Member 10, Apo-2 Ligand, Apo-2L, TNF-Related Apoptosis-Inducing Ligand, Protein TRAIL, CD253, TNFSF10, APO2L, TRAIL Accession # P50591 Formulation Lyophilized from a 0.2 μm filtered solution of PBS，pH 7.4 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIH EKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSI YQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVGLEHHHHHH*Background Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.