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C326
Recombinant Human DR5/TRAIL R2/TNFRSF10B
10ug
320
288
现货
国产
-
C326
Recombinant Human DR5/TRAIL R2/TNFRSF10B
50ug
960
864
现货
国产
-
C326
Recombinant Human DR5/TRAIL R2/TNFRSF10B
500ug
6160
5544
现货
国产
-
C326
Recombinant Human DR5/TRAIL R2/TNFRSF10B
1mg
8800
7920
现货
国产
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C326
Recombinant Human TRAIL R2/TNFRSF10B/DR5
10ug
320
288
现货
国产
-
C326
Recombinant Human TRAIL R2/TNFRSF10B/DR5
50ug
960
864
现货
国产
-
C326
Recombinant Human TRAIL R2/TNFRSF10B/DR5
500ug
6160
5544
现货
国产
-
C326
Recombinant Human TRAIL R2/TNFRSF10B/DR5
1mg
8800
7920
现货
国产
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Catalog# C326 Source HEK293 Description Recombinant Human TNF-Related Apoptosis-Inducing Ligand Receptor 2/TRAIL-R2 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Ile56-Glu182) of Human TRAILR2 fused with a polyhistidine tag at the C-terminus. Names Tumor Necrosis Factor Receptor Superfamily Member 10B, Death Receptor 5, TNF-Related Apoptosis-Inducing Ligand Receptor 2, TRAIL Receptor 2, TRAIL-R2, CD262, TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9 Accession # O14763 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence ITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCD SGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKEVDH HHHHBackground TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.