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C261
Recombinant Human Tropomyosin α-1 chain/TPM1
10ug
1200
1080
现货
国产
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C261
Recombinant Human Tropomyosin α-1 chain/TPM1
50ug
3520
3168
现货
国产
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C261
Recombinant Human Tropomyosin α-1 chain/TPM1
500ug
12320
11088
现货
国产
-
C261
Recombinant Human Tropomyosin α-1 chain/TPM1
1mg
17600
15840
现货
国产
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Catalog# C261 Source E.coli Description Recombinant Human Tropomyosin α-1 Chain/TPM1 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Met284) of Human TPM1 fused with a His tag at the N-terminus. Names Tropomyosin Alpha-1 Chain, Alpha-Tropomyosin, Tropomyosin-1, TPM1, C15orf13, TMSA Accession # P09493 Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris, 1mM DTT, 100mM NaCl, 20% Glycerol, pH 8.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence MGSSHHHHHHSSGLVPRGSHMDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVS LQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATAL QKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESD LERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAE FAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSMBackground Tropomyosin α-1 Chain (TPM1) is a member of the Tropomyosin family of highly conserved and widely distributed Actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM1 binds to Actin filaments in both muscle and non-muscle cells. It is one type of α-helical chain that forms the predominant Tropomyosin of striated muscle. TPM1 plays a central role in association with the Troponin complex and the Calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with Caldesmon. In non-muscle cells, it is implicated in stabilizing the cytoskeleton Actin filaments. Defects in TPM1 are associated with type 3 Familial Hypertrophic Cardiomyopathy.