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CG32
Recombinant Human Tryptophan 5-hydroxylase 2/TPH-2
10ug
1200
1080
现货
国产
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CG32
Recombinant Human Tryptophan 5-hydroxylase 2/TPH-2
50ug
3520
3168
现货
国产
-
CG32
Recombinant Human Tryptophan 5-hydroxylase 2/TPH-2
500ug
13440
12096
现货
国产
-
CG32
Recombinant Human Tryptophan 5-hydroxylase 2/TPH-2
1mg
19200
17280
现货
国产
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Catalog# CG32 Source E.coli Description Recombinant Human Tryptophan 5-Hydroxylase 2/TPH2 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ile496) of Human TPH2 fused with a His tag at the N-terminus. Names Tryptophan 5-Hydroxylase 2, Neuronal Tryptophan Hydroxylase, Tryptophan 5-Monooxygenase 2, TPH2, NTPH Accession # Q14CC5 Formulation Supplied as a 0.2 μm filtered solution of PBS, pH 7.4 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MNHKVHHHHHHMQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTASTFLKLNKPNSGKNDDKG NKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCE CGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDAD HPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNF PLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDP LYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQL RAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKS ITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGIVDLQSRBackground Tryptophan 5-hydroxylase 2 (TPH2) is an isozyme member of the biopterin-dependent aromatic amino acid hydroxylase family. TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression found in the raphe nucleus of the midbrain. TPH2 catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD). Defects in TPH2 are the cause of psychiatric diseases such as bipolar affective disorder and major depression.