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CG45
Recombinant Human UBE2K/Ubiquitin-conjugating enzyme E2 K
10ug
240
216
现货
国产
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CG45
Recombinant Human UBE2K/Ubiquitin-conjugating enzyme E2 K
50ug
720
648
现货
国产
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CG45
Recombinant Human UBE2K/Ubiquitin-conjugating enzyme E2 K
500ug
4800
4320
现货
国产
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CG45
Recombinant Human UBE2K/Ubiquitin-conjugating enzyme E2 K
1mg
7600
6840
现货
国产
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Catalog# CG45 Source E.coli Description Recombinant Human Ubiquitin-Conjugating Enzyme E2 K/UBE2K is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Asn200) of Human UBE2K fused with a 6His tag at the N-terminus. Names Ubiquitin-Conjugating Enzyme E2 K, Huntingtin-Interacting Protein 2, HIP-2, Ubiquitin Carrier Protein, Ubiquitin-Conjugating Enzyme E2-25 kDa, Ubiquitin-Conjugating Enzyme E2(25K), Ubiquitin-Conjugating Enzyme E2-25K, Ubiquitin-Protein Ligase, UBE2K, HIP2 Accession # P61086 Formulation Supplied as a 0.2 μm filtered solution of PBS, pH 7.4 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MGHHHHHHGSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQG KEMDSLRFLYDGIRIQADQAPEDLDMEDNDIIEAHREQIGGMANIAVQRIKREFKEVLKSEETSK NQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTG AICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAG APVSSPEYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLSNBackground Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with huntingtin, and MHC-heavy chain proteins.