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C186
Recombinant Human UBE2K/Ubiquitin-conjugating enzyme E2 K/E2-25K(GST)
10ug
240
216
现货
国产
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C186
Recombinant Human UBE2K/Ubiquitin-conjugating enzyme E2 K/E2-25K(GST)
50ug
600
540
现货
国产
-
C186
Recombinant Human UBE2K/Ubiquitin-conjugating enzyme E2 K/E2-25K(GST)
500ug
5040
4536
现货
国产
-
C186
Recombinant Human UBE2K/Ubiquitin-conjugating enzyme E2 K/E2-25K(GST)
1mg
7200
6480
现货
国产
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Catalog# C186 Source E.coli Description Recombinant Human Ubiquitin-Conjugating Enzyme E2 K/UBE2K is produced by our E. coli expression system. The target protein is expressed with sequence (Ala2-Asn200) of Human UBE2K fused with a GST tag at the N-terminus. Names Ubiquitin-Conjugating Enzyme E2 K, Huntingtin-Interacting Protein 2, HIP-2, Ubiquitin Carrier Protein, Ubiquitin-Conjugating Enzyme E2-25 kDa, Ubiquitin-Conjugating Enzyme E2(25K), Ubiquitin-Conjugating Enzyme E2-25K, Ubiquitin-Protein Ligase, UBE2K, HIP2 Accession # P61086 Formulation Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKL TQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEML KMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKS SKYIAWPLQGWQATFGGGDHPPKSDLVPRGSMANIAVQRIKREFKEVLKSEETSKNQIKVDLVDE NFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQ WAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTK KIENLCAMGFDRNAVIVALSSKSWDVETATELLLSNBackground Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with huntingtin, and MHC-heavy chain proteins.