产品中心
-
产品货号
产品名称
规格
销售价
会员价
货期
产地
订购
-
CG40
Recombinant Human ISG15/UCRP
10ug
360
324
现货
国产
-
CG40
Recombinant Human ISG15/UCRP
50ug
840
756
现货
国产
-
CG40
Recombinant Human ISG15/UCRP
500ug
8960
8064
现货
国产
-
CG40
Recombinant Human ISG15/UCRP
1mg
12800
11520
现货
国产
-
CG40
Recombinant Human Ubiquitin-like protein ISG15/UCRP/ISG15
10ug
360
324
现货
国产
-
CG40
Recombinant Human Ubiquitin-like protein ISG15/UCRP/ISG15
50ug
840
756
现货
国产
-
CG40
Recombinant Human Ubiquitin-like protein ISG15/UCRP/ISG15
500ug
8960
8064
现货
国产
-
CG40
Recombinant Human Ubiquitin-like protein ISG15/UCRP/ISG15
1mg
12800
11520
现货
国产
- 产品简介
- 使用说明
- 相关产品
- 参考文献
- 购买咨询
Catalog# CG40 Source E.coli Description Recombinant Human Ubiquitin-Like Protein ISG15/ISG15 is produced with our E. coli expression system. The target protein is expressed with sequence (Gly2-Gly157) of Human ISG15 fused with a 6His tag at the C-terminus. Names Ubiquitin-Like Protein ISG15, Interferon-Induced 15 kDa Protein, Interferon-Induced 17 kDa Protein, IP17, Ubiquitin Cross-Reactive Protein, hUCRP, ISG15, G1P2, UCRP Accession # P05161 Formulation Supplied as a 0.2 μm filtered solution of 50mM HEPES, 100mM NaCl, pH 8.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MGWDLTVKMLAGNEFQVSLSSSMSVSELKAQITQKIGVHAFQQRLAVHPSGVALQDRVPLASQGL GPGSTVLLVVDKCDEPLNILVRNNKGRSSTYEVRLTQTVAHLKQQVSGLEGVQDDLFWLTFEGKP LEDQLPLGEYGLKPLSTVFMNLRLRGGLEHHHHHHBackground Ubiquitin-Like Protein ISG15 (ISG15) is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. ISG15 becomes conjugated to a diverse set of proteins after IFN-alpha/beta stimulation or microbial challenge. The functions or biochemical consequences ISG15 conjugation to proteins are not yet known, but it appears that this modification does not target proteins for proteasomal degradation. ISG15 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. Upon interferon treatment, ISG15 can be detected in both free and conjugated forms, and is secreted from monocytes and lymphocytes where it can function as a cytokine. In the cell, ISG15 co-localizes with intermediate filaments and ISGylation may modulate the JAK-STAT pathway or certain aspects of neurological disease.