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C038
Recombinant Human TNFSF15/VEGI 192
10ug
936
842.4
现货
国产
-
C038
Recombinant Human TNFSF15/VEGI 192
50ug
2800
2520
现货
国产
-
C038
Recombinant Human TNFSF15/VEGI 192
500ug
14800
13320
现货
国产
-
C038
Recombinant Human TNFSF15/VEGI 192
1mg
21120
19008
现货
国产
-
C038
Recombinant Human VEGI 192/TNFSF15
10ug
936
842.4
现货
国产
-
C038
Recombinant Human VEGI 192/TNFSF15
50ug
2800
2520
现货
国产
-
C038
Recombinant Human VEGI 192/TNFSF15
500ug
14800
13320
现货
国产
-
C038
Recombinant Human VEGI 192/TNFSF15
1mg
21120
19008
现货
国产
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Catalog# C038 Source E.coli Description Recombinant Human Tumor Necrosis Factor Ligand Superfamily Member 15/TNFSF15 produced in E. coli is a single non-glycosylated polypeptide chain containing 192 amino acids with a molecular mass of 21,858 Daltons. Names Tumor Necrosis Factor Ligand Superfamily Member 15, TNF Ligand-Related Molecule 1, Vascular Endothelial Cell Growth Inhibitor, TNFSF15, TL1, VEGI Accession # O95150-2 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.5 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Biological Activity ED50 is less than 5 μg/ml as determined by the dose-dependent inhibition of the proliferation of HUVEC cells. Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence MQLTKGRLHFSHPLSHTKHISPFVTDAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELG LAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYP EPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLLBackground Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.